The analysis of continuous data from N-of-1 trials using paired cycles: a simple tutorial

Author: Stephen Senn

The article titled "The analysis of continuous data from n-of-1 trials using paired cycles: a simple tutorial" by Stephen Senn provides a tutorial on analysing continuous data from n-of-1 trials using paired cycle designs. N-of-1 trials are individualised studies comparing two treatments within a single patient, making them particularly useful for chronic conditions where patient responses may vary.

The tutorial introduces the paired cycle design, explains how to construct suitable sequences, and discusses various analytical approaches, all illustrated with simulated data. This methodology is a valuable framework as, by structuring the trial into paired treatment cycles, researchers can directly compare the effects of two treatments within the same individual, reducing the impact of external factors such as lifestyle changes or seasonal variations. Furthermore, when multiple n-of-1 trials employ paired cycles, their results can be aggregated similarly to a meta-analysis in parallel-group trials. This enhances the generalisability of findings while maintaining the focus on individualised treatment decisions.

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Full reference: Senn, S. (2024). The analysis of continuous data from n-of-1 trials using paired cycles: a simple tutorial. Trials, 25(1), 128.