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single case research design 3rd ed cover

Single-Case Research Designs: Methods for Clinical and Applied Settings (3rd Edition). Alan Kazdin, 2020

Single-case research has played an important role in developing and evaluating interventions that are designed to alter a particular facet of human functioning. Now thoroughly updated in its second edition, acclaimed author Alan E. Kazdin’s Single-Case Research Designs provides a notable contrast to the quantitative methodology approach that pervades the biological and social sciences. While focusing on widely applicable methodologies for evaluating interventions–such as treatment or psychotherapy using applied behavior analysis–this revised edition also encompasses a broader range of research areas that utilize single-case designs, demonstrating the pertinence of this methodology in various disciplines, from psychology and medicine to business and industry. Please click here for further information.

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Single-Case Experimental Designs for Clinical Research and Neurorehabilitation Settings: Planning, Conduct, Analysis and ReportingRobyn Tate & Michael Perdices, 2018

This book is a practical resource designed for clinicians, researchers, and advanced students who wish to learn about single-case research designs. It covers the theoretical and methodological underpinnings of single-case designs, as well as their practical application in the clinical and research neurorehabilitation setting. The book briefly traces the history of single-case experimental designs (SCEDs); outlines important considerations in understanding and planning a scientifically rigorous single-case study, including internal and external validity; describes prototypical single-case designs (withdrawal-reversal designs and the medical N-of-1 trial, multiple-baseline designs, alternating-treatments designs, and changing-criterion designs) and required features to meet evidence standards, threats to internal validity, and strategies to address them; addresses data evaluation, covering visual analysis of graphed data, statistical techniques, and clinical significance; and provides a practical 10-step procedure for implementing single-case methods. Each chapter includes detailed illustrative examples from the neurorehabilitation literature. Please click here for further information.

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The Essential Guide to N-of-1 Trials in Health. Jane Nikles & Geoffrey Mitchell, 2015

N-of-1 trials, a type of individualized randomized controlled trial, are relevant to almost every discipline in medicine and psychology. They can tell the clinician with precision whether a treatment works in that individual, which distinguishes from the information available from most other trial designs.  They have the potential to revolutionize the way clinical medicine is practiced. Whether you are a busy clinician, a researcher or a student, this book provides everything you need to know about N-of-1 trials. Written and edited by some of the world’s leading experts on N-of-1 trials, the book presents state of the art knowledge about N-of-1 trials, with chapters on ethics, statistics, health economics, design, analysis and reporting, and more.  Full of examples and well illustrated, it is a comprehensive compendium of issues surrounding the design, conduct, interpretation and implementation of N-of-1 trials in a health system. For further information, and access to standalone chapters, please click here


Single-case and Small-n Experimental Designs: A Practical Guide To Randomization Tests (2nd Edition). Pat Dugard, Portia File & Johnathan Todman, 2011

This practical guide explains the use of randomization tests and provides example designs and macros for implementation in IBM SPSS and Excel. It reviews the theory and practice of single-case and small-ndesigns so readers can draw valid causal inferences from small-scale clinical studies. The macros and example data are provided on the book’s website so that users can run analyses of the text data as well as data from their own studies. Ideal as a text for courses on single-case, small n design, and/or randomization tests taught at the graduate level in psychology (especially clinical, counseling, educational, and school), education, human development, nursing, and other social and health sciences, this inexpensive book also serves as a supplement in statistics or research methods courses. Practitioners and researchers with an applied clinical focus also appreciate this book’s accessible approach. An introduction to basic statistics, SPSS, and Excel is assumed. Please click here for further information. 


Single Case Experimental Designs: Strategies for Studying Behavior Change (3rd Edition). David Barlow, Matthew Nock & Michael Hersen, 2009 

The purpose of this book is to provide a comprehensive sourcebook on single case experimental designs with practical guidelines for their use in a range of research and clinical settings.  It is suitable for use as a textbook for a course on research methodology or clinical assessment and treatment, or as a desk reference for seasoned researchers and practicing clinicians. Written in a non-technical style, this book is designed to be accessible to individuals from a range of backgrounds including advanced undergraduates, graduate students, researchers, and mental health practitioners–and to those working from a wide range of perspectives, including clinical psychology, educational or school psychology, social work, psychiatry, nursing, and other fields focused on human behavior change. Please click here for further information. 


Single Subject Designs in Biomedicine draws upon the rich history of single case research within the educational and behavioral research settings and extends the application to the field of biomedicine. Biomedical illustrations are used to demonstrate the processes of designing, implementing, and evaluating a single subject design. Strengths and limitations of various methodologies are presented, along with specific clinical areas of application in which these applications would be appropriate. Statistical and visual techniques for data analysis are also discussed. The breadth and depth of information provided is suitable for medical students in research oriented courses, primary care practitioners and medical specialists seeking to apply methods of evidence practice to improve patient care, and medical researchers who are expanding their methodological expertise to include single subject designs. Increasing awareness of the utility in the single subject design could enhance treatment approach and evaluation both in biomedical research and medical care settings. Please click here for further information.

Single Subject Designs in Biomedicine. Janine Janosky, Shelley Leininger, Michael Hoerger & Terry Libkuman, 2009

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