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  • Nikles, J., Evans, K., Hams, A., & Sterling, M. (2022). A systematic review of N-of-1 trials and single case experimental designs in physiotherapy for musculoskeletal conditions. Musculoskeletal Science and Practice, 102639. Click here to access.

  • Stunnenberg, B. C., Berends, J., Griggs, R. C., Statland, J., Drost, G., Nikles, J., ... & Raaphorst, J. (2022). N-of-1 Trials in Neurology: A Systematic Review. Neurology, 98(2), e174-e185. Click here to access.

  • Samuel, J. P., Wootton, S. H., Holder, T., & Molony, D. (2022). A scoping review of randomized trials assessing the impact of n-of-1 trials on clinical outcomes. PloS one, 17(6), e0269387. Click here to access

  • Jamshidi, L., Heyvaert, M., Declercq, L., Fernández-Castilla, B., Ferron, J. M., Moeyaert, M., ... & Van den Noortgate, W. (2022). A systematic review of single-case experimental design meta-analyses: Characteristics of study designs, data, and analyses. Evidence-Based Communication Assessment and Intervention, 1-25. Click here to access.

  • Müller, A. R., Brands, M. M., van de Ven, P. M., Roes, K. C., Cornel, M. C., van Karnebeek, C. D., ... & van Eeghen, A. M. (2021). Systematic review of N-of-1 studies in rare genetic neurodevelopmental disorders: the power of 1. Neurology, 96(11), 529-540. Click here to access.

  • Shaffer, J. A., Kronish, I. M., Falzon, L., Cheung, Y. K., & Davidson, K. W. (2018). N-of-1 randomized intervention trials in health psychology: a systematic review and methodology critique. Annals of Behavioral Medicine, 52(9), 731-742.​ Click here to access.

  • Smith, J. D. (2012). Single-case experimental designs: A systematic review of published research and current standards. Psychological Methods, 17(4), 510. Click here to access

  • Gabler, N. B., Duan, N., Vohra, S., & Kravitz, R. L. (2011). N-of-1 trials in the medical literature: a systematic review. Medical Care, 49(8), 761-768. Click here to access



  • Nikles, J., Daza, E. J., McDonald, S., Hekler, E., & Schork, N. J. (2021). Creating evidence from real world patient digital data. Frontiers in Computer Science, 2, 636996. Click here to access

  • Ganz, J. B., & Ayres, K. M. (2018). Methodological standards in single-case experimental design: Raising the bar. Research in Developmental Disabilities, 79, 3-9. Click here to access

  • Machalicek, W., & Horner, R. H. (2018). Special issue on advances in single-case research design and analysis. Developmental Neurorehabilitation, 21(4), 209-211. Click here to access.

  • ​Vohra, S. (2016). N-of-1 trials to enhance patient outcomes: identifying effective therapies and reducing harms, one patient at a time. Journal of Clinical Epidemiology, 76, 6-8. Click here to access

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