This paper explores how the Multiphase Optimization STrategy (MOST) can be combined with single-case experimental designs to optimise behavioural interventions, highlighting opportunities to develop more adaptive, personalised, and equitable evidence-based interventions.

The article titled "Personality psychology is getting personal: Advancing the field through personalization" by Modersitzki, Phan, McDonald, Wright, and Renner explores how the field of psychology can be strengthened by embracing personalisation in its theoretical frameworks, measurement strategies, and methodological designs. The authors argue that traditional psychological research, which focuses primarily on population-level traits and between-person variability, falls sho

This tutorial introduces paired cycle designs for analysing continuous data in N-of-1 trials, demonstrating how they strengthen within-patient treatment comparisons and support the aggregation of findings across multiple trials.

This prospective multicentre N-of-1 trial evaluates deep brain stimulation for severe dystonia associated with Wilson disease, providing important evidence on its effectiveness, safety, and implications for managing this challenging rare condition.

Authors: Badesha, Wilde & Dawson (2022) This study aimed to investigate the utility of a mental health app, underpinned by cognitive behavioral therapy (CBT), in reducing psychological distress among adolescents. The study used a multiple-baseline single-case experimental design, tracking variables across baseline and intervention phases and also administered surveys assessing participant experience. Five participants with moderate-to-severe levels of psychological distress e

Authors: Manolov, Onghena & Van den Noorgate (2021) The authors of the article suggest that multi-level models can be used to include...

Authors: Zenner, Böttinger & Konigorski, 2022 This article introduces ‘StudyMe’, an open-source mobile application that aims to support...

Authors: Zarbin & Novack (2021) This article focuses on Retinitis Pigmentosa (RP), a group of inherited retinal degenerative diseases...

Authors: Müller, Brands, van de Ven, Roes, Cornel, van Karnebeek, ... & van Eeghen, A. M. (2021) Genetic neurodevelopmental disorders are...

Authors: Stunnenberg, Merkus, Raaphorst, Saris, Groenewoud, Statland, ... & van der Wilt (2021). Hyperkalemic periodic paralysis...

Authors: Herrett, Williamson, Brack, Beaumont, Perkins, Thayne, ... & Smeeth (2021). A recent BMJ article demonstrated the value of N-of-1 trials for exploring side effects of statins, a drug taken by millions of people worldwide for the primary and secondary prevention of cardiovascular events. Despite their effectiveness in reducing the risk of cardiovascular events such as heart attacks and strokes, there have been many reports of patients discontinuing statins after they

Natesan, Nandakumar, Palka & Shrestha (2021) Visual analysis has been a common tool used to analyse single-case experimental design...

Authors: Senarathne, Overstall & McGree (2020) A recent article in Statistics in Medicine proposes an adaptive N-of-1 framework where...

This selected article is about Consecutive Controlled Case Series

Krone et al. (2020) test whether meta-analysis or linear mixed-modelling approaches are best aggregating N-of-1 data

Authors: McDonald, Vieira & Johnston (2020)

Authors: Simons, Harrison, O'Brien, Heirich, Loecher, Boothroyd, Vlaeyen, Wicksell, Schofield, Hood, Orendurff, Chan & Lyons (2019) This...

Selected article written by Wicks (2019)

Selected paper written by Lian Liu, Yue Zhang, Jia Wei, Zhaoxin Chen, and Jing Yu (2019)

Read this month's ICN selected paper!