Single-Case Studies as a Hot Topic in Pain Research: A Conference Review
Author: Sara Laureen Bartels The 12th Congress of the European Pain Federation EFIC 2022 took place in Dublin in a hybrid format from...
The International Collaborative Network for N-of-1 Trials and Single-Case Designs
BLOGS AND SELECTED PAPERS
New blogs and selected papers are added on a monthly basis. To receive updates about new posts by email, please join the ICN.
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- Jun 30
- 2 min
N-of-1 Trials: A Scientific Approach to Personalised Medicine for Patients with Rare Retinal Disease
Authors: Zarbin & Novack (2021) This article focuses on Retinitis Pigmentosa (RP), a group of inherited retinal degenerative diseases...
58 views0 comments
- May 13
- 1 min
N-of-1 Trials in Pediatric Oncology: From a Population-Based Approach to Personalized Medicine
Authors: Kyr, Svobodnik, Stepanova & Hejnova (2021) Clinical trials in paediatric oncology are often focused on rare diseases. However,...
95 views0 comments
- May 13
- 5 min
An Interview with Professor Nicholas Schork, Thought Leader in the Field of Single-Case Designs
Dr. Nicholas Schork is Deputy Director and Distinguished Professor of Quantitative Medicine at The Translational Genomics Research...
186 views0 comments
- Aug 22, 2021
- 6 min
Brave New World of Health Care Consumerism, N-of-1, and Character of Health Type
Author: Browning Rockwell, WeWa.life The ICN is a noncommercial entity that receives no funding and is run by volunteers. The ICN...
120 views0 comments
- Aug 22, 2021
- 2 min
Systematic Review of N-of-1 Studies in Rare Genetic Neurodevelopmental Disorders: The Power of 1
Authors: Müller et al. Genetic neurodevelopmental disorders are often presented with various degrees of severity and complex syndromes,...
134 views0 comments
- Jul 1, 2021
- 1 min
N-of-1 trial of salbutamol in hyperkalaemic periodic paralysis
Authors: Stunnenberg BC, Merkus EC, Raaphorst J, et al Hyperkalemic periodic paralysis (HyperPP) is a rare neurological channelopathy...
57 views0 comments
- Jul 1, 2021
- 5 min
Implementing Single-Case Designs in Complementary and Alternative Medicine Trials
Authors: Joanne Bradbury and Sandra Grace In many ways, N-of-1 trials are well-suited to complementary and alternative medicine (CAM)...
117 views0 comments
- May 31, 2021
- 4 min
Who Will Benefit from Which Diet: Can N-of-1 Studies Fill a Gap in the Care of Adult PKU?
Authors: Maria Depenweiller, Kathryn Moseley, Kirsten Ahring, Ash Morgan Chambers & Annie Prince In phenylketonuria (PKU), a rare...
128 views0 comments
- May 31, 2021
- 4 min
Small is Beautiful {Again}: An Overview of the Second International Online N=1 Symposium
Author: Livia Guadagnoli Small is Beautiful {Again}, the second international online N=1 symposium, took place April 14-16, 2021. Over...
232 views0 comments
- May 31, 2021
- 2 min
Statin Treatment and Muscle Symptoms: Series of Randomised, Placebo Controlled N-of-1 Trials
Authors: Herrett E, Williamson E, Brack K, Beaumont D, Perkins A, Thayne A et al. A recent BMJ article demonstrated the value of N-of-1...
74 views0 comments
- Mar 30, 2021
- 5 min
Will the Real Mr. Average Please Stand Up?
Authors: Anne MacGregor & Alec Mian We can easily recognize the face of someone we know from thousands if not millions of other humans....
180 views1 comment
- Mar 30, 2021
- 1 min
Comparing the Bayesian Unknown Change-Point Model and Simulation Modeling Analysis to Analyze SCEDs
Natesan, Nandakumar, Palka & Shrestha (2021) Visual analysis has been a common tool used to analyse single-case experimental design...
66 views0 comments
- Nov 30, 2020
- 1 min
Bayesian Adaptive N-of-1 trials for Estimating Population and Individual Treatment Effects
Senarathne, Overstall & McGree (2020) A recent article in Statistics in Medicine proposes an adaptive N-of-1 framework where treatment...
156 views0 comments
- Nov 30, 2020
- 4 min
N-of-1 Trials are Valuable Scientific Methods for Precision Medicine
Authors: Suzanne McDonald, James McGree & Jane Nikles We were interested to see the reference to N-of-1 trials in the article by...
436 views0 comments
- Oct 31, 2020
- 1 min
The Consecutive Controlled Case Series: Design, Data-Analytics, Reporting Methods and Generality
This selected article is about Consecutive Controlled Case Series
158 views0 comments
- Oct 31, 2020
- 4 min
Creating Evidence from Real World Patient Digital Data
Authors: Jane Nikles, Eric J. Daza, Suzanne McDonald, Eric Hekler and Nicholas Schork The number of published N-of-1 articles has doubled...
335 views0 comments
- Jun 30, 2020
- 2 min
The Possibilities of the Use of N-of-1 and Do-It-Yourself Trials in Nutritional Research
Krone et al. (2020) test whether meta-analysis or linear mixed-modelling approaches are best aggregating N-of-1 data
49 views0 comments
- Jun 30, 2020
- 5 min
N-of-1 Trials in Practice: A Training Program for Complementary Medicine Practitioners
Dr Joanne Bradbury and Professor Sandra Grace discuss a training program for complementary medicine practitioners
55 views0 comments
- May 31, 2020
- 3 min
Progress Towards Priorities for the International Collaborative Network for N-of-1 Trials and SCDs
Describes progress towards priorities for the ICN
79 views0 comments