Blog

BLOGS AND SELECTED PAPERS

New blogs and selected papers are added on a monthly basis. To receive updates about new posts by email, please join the ICN.

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May 13
1 min

N-of-1 Trials in Pediatric Oncology: From a Population-Based Approach to Personalized Medicine

Authors: Kyr, Svobodnik, Stepanova & Hejnova (2021) Clinical trials in paediatric oncology are often focused on rare diseases. However,...

46 views0 comments

May 13
5 min

An Interview with Professor Nicholas Schork, Thought Leader in the Field of Single-Case Designs

Dr. Nicholas Schork is Deputy Director and Distinguished Professor of Quantitative Medicine at The Translational Genomics Research...

115 views0 comments

Aug 21, 2021
6 min

Brave New World of Health Care Consumerism, N-of-1, and Character of Health Type

Author: Browning Rockwell, WeWa.life The ICN is a noncommercial entity that receives no funding and is run by volunteers. The ICN...

107 views0 comments

Aug 21, 2021
2 min

Systematic Review of N-of-1 Studies in Rare Genetic Neurodevelopmental Disorders: The Power of 1

Authors: Müller et al. Genetic neurodevelopmental disorders are often presented with various degrees of severity and complex syndromes,...

124 views0 comments

Jun 30, 2021
1 min

N-of-1 trial of salbutamol in hyperkalaemic periodic paralysis

Authors: Stunnenberg BC, Merkus EC, Raaphorst J, et al Hyperkalemic periodic paralysis (HyperPP) is a rare neurological channelopathy...

51 views0 comments

Jun 30, 2021
5 min

Implementing Single-Case Designs in Complementary and Alternative Medicine Trials

Authors: Joanne Bradbury and Sandra Grace In many ways, N-of-1 trials are well-suited to complementary and alternative medicine (CAM)...

110 views0 comments

May 31, 2021
4 min

Who Will Benefit from Which Diet: Can N-of-1 Studies Fill a Gap in the Care of Adult PKU?

Authors: Maria Depenweiller, Kathryn Moseley, Kirsten Ahring, Ash Morgan Chambers & Annie Prince In phenylketonuria (PKU), a rare...

120 views0 comments

May 31, 2021
4 min

Small is Beautiful {Again}: An Overview of the Second International Online N=1 Symposium

Author: Livia Guadagnoli Small is Beautiful {Again}, the second international online N=1 symposium, took place April 14-16, 2021. Over...

192 views0 comments

May 30, 2021
2 min

Statin Treatment and Muscle Symptoms: Series of Randomised, Placebo Controlled N-of-1 Trials

Authors: Herrett E, Williamson E, Brack K, Beaumont D, Perkins A, Thayne A et al. A recent BMJ article demonstrated the value of N-of-1...

71 views0 comments

Mar 30, 2021
5 min

Will the Real Mr. Average Please Stand Up?

Authors: Anne MacGregor & Alec Mian We can easily recognize the face of someone we know from thousands if not millions of other humans....

176 views1 comment

Mar 30, 2021
1 min

Comparing the Bayesian Unknown Change-Point Model and Simulation Modeling Analysis to Analyze SCEDs

Natesan, Nandakumar, Palka & Shrestha (2021) Visual analysis has been a common tool used to analyse single-case experimental design...

64 views0 comments

Nov 30, 2020
1 min

Bayesian Adaptive N-of-1 trials for Estimating Population and Individual Treatment Effects

Senarathne, Overstall & McGree (2020) A recent article in Statistics in Medicine proposes an adaptive N-of-1 framework where treatment...

154 views0 comments

Nov 30, 2020
4 min

N-of-1 Trials are Valuable Scientific Methods for Precision Medicine

Authors: Suzanne McDonald, James McGree & Jane Nikles We were interested to see the reference to N-of-1 trials in the article by...

422 views0 comments

Oct 31, 2020
1 min

The Consecutive Controlled Case Series: Design, Data-Analytics, Reporting Methods and Generality

This selected article is about Consecutive Controlled Case Series

153 views0 comments

Oct 31, 2020
4 min

Creating Evidence from Real World Patient Digital Data

Authors: Jane Nikles, Eric J. Daza, Suzanne McDonald, Eric Hekler and Nicholas Schork The number of published N-of-1 articles has doubled...

334 views0 comments

Jun 30, 2020
2 min

The Possibilities of the Use of N-of-1 and Do-It-Yourself Trials in Nutritional Research

Krone et al. (2020) test whether meta-analysis or linear mixed-modelling approaches are best aggregating N-of-1 data

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Jun 29, 2020
5 min

N-of-1 Trials in Practice: A Training Program for Complementary Medicine Practitioners

Dr Joanne Bradbury and Professor Sandra Grace discuss a training program for complementary medicine practitioners

50 views0 comments

May 31, 2020
3 min

Progress Towards Priorities for the International Collaborative Network for N-of-1 Trials and SCDs

Describes progress towards priorities for the ICN

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May 30, 2020
1 min

Analysing N-of-1 Observational Data: A 10-Step SPSS Tutorial for Beginners

Authors: McDonald, Vieira & Johnston (2020)

400 views0 comments

Jan 30, 2020
1 min

Protocol for a Randomized Controlled Trial Enhanced with Single-Case Experimental Design

Selected article written by Simons, Harrison, O'Brien, Heirich, Loecher, Boothroyd, Vlaeyen, Wicksell, Schofield, Hood, Orendurff, Chan &...

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