Short blogs

BLOGS AND SELECTED PAPERS

New blogs and selected papers are added on a monthly basis. To receive updates about new posts by email, please join the ICN.

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Jun 30
5 min

Implementing Single-Case Designs in Complementary and Alternative Medicine Trials

Authors: Joanne Bradbury and Sandra Grace In many ways, N-of-1 trials are well-suited to complementary and alternative medicine (CAM)...

61 views0 comments

May 31
4 min

Who Will Benefit from Which Diet: Can N-of-1 Studies Fill a Gap in the Care of Adult PKU?

Authors: Maria Depenweiller, Kathryn Moseley, Kirsten Ahring, Ash Morgan Chambers & Annie Prince In phenylketonuria (PKU), a rare...

86 views0 comments

Mar 30
5 min

Will the Real Mr. Average Please Stand Up?

Authors: Anne MacGregor & Alec Mian We can easily recognize the face of someone we know from thousands if not millions of other humans....

137 views1 comment

Nov 30, 2020
4 min

N-of-1 Trials are Valuable Scientific Methods for Precision Medicine

Authors: Suzanne McDonald, James McGree & Jane Nikles We were interested to see the reference to N-of-1 trials in the article by...

305 views0 comments

Oct 31, 2020
4 min

Creating Evidence from Real World Patient Digital Data

Authors: Jane Nikles, Eric J. Daza, Suzanne McDonald, Eric Hekler and Nicholas Schork The number of published N-of-1 articles has doubled...

321 views0 comments

Jun 29, 2020
5 min

N-of-1 Trials in Practice: A Training Program for Complementary Medicine Practitioners

Dr Joanne Bradbury and Professor Sandra Grace discuss a training program for complementary medicine practitioners

45 views0 comments

May 31, 2020
3 min

Progress Towards Priorities for the International Collaborative Network for N-of-1 Trials and SCDs

Describes progress towards priorities for the ICN

75 views0 comments

Jan 30, 2020
3 min

Visualization of Individual Data: A Powerful Tool in Personalized Medicine

Authors: Kenneth Shulman, Amparo Casanova & Marina Vives-Metres

123 views0 comments

Sep 30, 2019
3 min

Going Paperless: How Digital Technology Can Shape the Field of N-of-1 Trials

Authors: Samuel Tan, Farhad Fatehi, Steve Donoghue and Sandy Bodner

163 views0 comments

Aug 30, 2019
3 min

N-of-1 Trials in CAM: The New Frontier for Generating Practice-Based Evidence?

Authors: Dr Joanne Bradbury, Prof Sandra Grace and Dr Cathy Avila A system of healthcare that does not recognise traditional...

107 views0 comments

May 31, 2019
2 min

The Rare Disease Registry and Analytics Platform: Paving the way forward for N-of-1 trials

Authors: Dr James McGree and Samuel Tan Progress towards a global rare disease registry An MTPConnect funded project is currently...

99 views0 comments

Apr 30, 2019
4 min

Is There a Role for N-of-1 Trials in Nutrition Research?

Author: Dr Veronique Chachay As a key component of evidence-based healthcare, nutrition research provides insight into a number of...

64 views0 comments

Mar 31, 2019
3 min

Evaluation of a Physical Activity Intervention for Individuals with Whiplash Associated Disorders

Authors: Dr Carrie Ritchie, Dr Kelly Clanchy, Dr Sean Tweedy, Dr Melissa Day, A/Prof. Jane Nikles, Prof. Robyn Tate, Prof. Michele...

56 views0 comments

Feb 28, 2019
4 min

Using N-of-1 Trials to Identify Responders to Melatonin for Sleep Disturbance in Parkinson's Disease

Study in progress! Authors: Dr Jane Nikles, A/Prof. John O’Sullivan, Prof. Geoff Mitchell, Dr Alex Ritchie, A/Prof. Simon Smith, Dr Hugh...

80 views0 comments

Jan 31, 2019
3 min

Effect of mexiletine on muscle stiffness in nondystrophic myotonia: aggregated N-of-1 trials

Full title: Effect of mexiletine on muscle stiffness in patients with nondystrophic myotonia evaluated using aggregated N-of-1 trials: a...

54 views0 comments

Dec 31, 2018
3 min

10 key take-home messages from an expert workshop on single-case methodology

Author: Dr Suzanne McDonald Single-case (or ‘n-of-1’) methodology provides researchers and clinicians with a flexible and rigorous...

80 views0 comments

Nov 30, 2018
3 min

Personalised treatments for acute whiplash injuries: A pilot study

Authors: Dr Jane Nikles and Sherin Jacob Study summary WORK IN PROGRESS! We are applying Bayesian modelling of prior data for a...

27 views1 comment

Oct 31, 2018
1 min

A spotlight on… Associate Professor James McGree

I’m James McGree, an Associate Professor of Statistics at the Queensland University of Technology, Brisbane, Australia and the ICN...

17 views0 comments

Aug 31, 2018
3 min

A Rationale for N-of-1 trials

Author: Samuel Tan Randomized controlled trials (RCTs) first rose to prominence in the mid-20th century, heralded as a systematic,...

50 views0 comments