Designing Robust N-of-1 Studies for Precision Medicine

Authors: Percha, B., Baskerville, E. B., Johnson, M., Dudley, J. T., & Zimmerman, N. (2019)

In this article the authors present simulation studies to demonstrate how various n-of-1 methodological designs, such as carryover effects, number/order of treatment periods and sampling frequency affect the ability to detect differences between treatments tested using N-of-1 trials. The simulation software developed is available on GitHub (please see the paper for more details about how to access the software). The authors conclude with a set of important recommendations for the design and optimisation of future N-of-1 trials.

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Full Citation: Percha, B., Baskerville, E. B., Johnson, M., Dudley, J. T., & Zimmerman, N. (2019). Designing robust N-of-1 studies for precision medicine: simulation study and design recommendations. Journal of Medical Internet Research, 21(4), e12641.