Selected papers

BLOGS AND SELECTED PAPERS

New blogs and selected papers are added on a monthly basis. To receive updates about new posts by email, please join the ICN.

We encourage readers to post comments about each blog and paper and to share these posts on social media. To follow the ICN on Twitter please click here.

Jun 30
1 min

N-of-1 trial of salbutamol in hyperkalaemic periodic paralysis

Authors: Stunnenberg BC, Merkus EC, Raaphorst J, et al Hyperkalemic periodic paralysis (HyperPP) is a rare neurological channelopathy...

21 views0 comments

May 30
2 min

Statin Treatment and Muscle Symptoms: Series of Randomised, Placebo Controlled N-of-1 Trials

Authors: Herrett E, Williamson E, Brack K, Beaumont D, Perkins A, Thayne A et al. A recent BMJ article demonstrated the value of N-of-1...

46 views0 comments

Mar 30
1 min

Comparing the Bayesian Unknown Change-Point Model and Simulation Modeling Analysis to Analyze SCEDs

Natesan, Nandakumar, Palka & Shrestha (2021) Visual analysis has been a common tool used to analyse single-case experimental design...

49 views0 comments

Nov 30, 2020
1 min

Bayesian Adaptive N-of-1 trials for Estimating Population and Individual Treatment Effects

Senarathne, Overstall & McGree (2020) A recent article in Statistics in Medicine proposes an adaptive N-of-1 framework where treatment...

128 views0 comments

Oct 31, 2020
1 min

The Consecutive Controlled Case Series: Design, Data-Analytics, Reporting Methods and Generality

This selected article is about Consecutive Controlled Case Series

99 views0 comments

Jun 30, 2020
2 min

The Possibilities of the Use of N-of-1 and Do-It-Yourself Trials in Nutritional Research

Krone et al. (2020) test whether meta-analysis or linear mixed-modelling approaches are best aggregating N-of-1 data

34 views0 comments

May 30, 2020
1 min

Analysing N-of-1 Observational Data: A 10-Step SPSS Tutorial for Beginners

Authors: McDonald, Vieira & Johnston (2020)

349 views0 comments

Jan 30, 2020
1 min

Protocol for a Randomized Controlled Trial Enhanced with Single-Case Experimental Design

Selected article written by Simons, Harrison, O'Brien, Heirich, Loecher, Boothroyd, Vlaeyen, Wicksell, Schofield, Hood, Orendurff, Chan &...

77 views0 comments

Sep 30, 2019
1 min

Patient, study thyself

Selected article written by Wicks (2019)

86 views0 comments

Aug 30, 2019
1 min

A Pilot Study of Amino Acids in Unresectable Non-Small-Cell Lung Cancer Patients During Chemotherapy

Selected paper written by Lian Liu, Yue Zhang, Jia Wei, Zhaoxin Chen, and Jing Yu (2019)

60 views0 comments

May 31, 2019
1 min

Designing Robust N-of-1 Studies for Precision Medicine

Read this month's ICN selected paper!

105 views0 comments

Apr 30, 2019
1 min

Personalised Nutrition and Health

Authors: Dr Jose M Ordovas, Dr Lynnette R Ferguson, Dr E Shyong Tai, Dr John C Mathers Summary: In this informative review, Ordovas and...

47 views0 comments

Mar 31, 2019
1 min

Meta-Analysis of Single-Case Research via Multilevel Models

Authors: Dr Mariola Moeyaert, Dr Rumen Manolov, and Dr Emily Rodabaugh Multilevel modeling is an approach that can be used to summarize...

40 views0 comments

Feb 28, 2019
1 min

A SCED Study on Improving Social Communication Skills after Traumatic Brain Injury

Authors: Dr Rachael Rietdijk, Emma Power, Melissa Brunner, Dr Leanne Togher Summary This paper describes a SCED to evaluate telehealth to...

30 views0 comments

Jan 31, 2019
1 min

Evaluation of person-level heterogeneity of treatment effects in multiperson N-of-1 studies

Full title: Evaluation of person-level heterogeneity of treatment effects in published multiperson N-of-1 studies: systematic review and...

71 views0 comments

Dec 31, 2018
1 min

Statistical pitfalls of personalized medicine

Author: Stephen Senn This article describes some key assumptions that have been made in personalised medicine. For example: There is a...

42 views0 comments

Oct 31, 2018
1 min

Methodological standards in single-case experimental design: Raising the bar

Authors: Dr Jennifer B Ganz and Dr Kevin M Ayres This paper summarises the recent history of methodological quality considerations in...

23 views0 comments

Aug 31, 2018
1 min

Randomized single-case AB phase designs: Prospects and pitfalls

Authors: Dr Bart Michiels and Dr Patrick Onghena This paper discusses the randomized AB single-case phase design. Randomized AB...

15 views0 comments

Jul 31, 2018
1 min

Melatonin in Youth: N-of-1 trials in a stimulant-treated ADHD Population (MYNAP): study protocol

Authors: Dr Salima Punja, Dr Catherine J. Nikles , Dr Hugh Senior, Dr Geoffrey Mitchell, Dr Christopher H. Schmid, Dr Helen Heussler, Dr...

24 views0 comments

Jun 30, 2018
1 min

Cognitive-Behavioral Treatment of Adult Rumination Behavior in the Setting of Disordered Eating

Authors: Dr Jennifer J Thomas and Helen B Murray This paper uses a single case experimental design for a patient that experienced an...

26 views0 comments

International Collaborative Network for

N-of-1 Clinical Trials and Single-Case Designs