N-of-1 Trials: A Scientific Approach to Personalised Medicine for Patients with Rare Retinal Disease
Authors: Zarbin & Novack (2021) This article focuses on Retinitis Pigmentosa (RP), a group of inherited retinal degenerative diseases...
The International Collaborative Network for N-of-1 Trials and Single-Case Designs
BLOGS AND SELECTED PAPERS
New blogs and selected papers are added on a monthly basis. To receive updates about new posts by email, please join the ICN.
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- Aug 22, 2021
- 2 min
Systematic Review of N-of-1 Studies in Rare Genetic Neurodevelopmental Disorders: The Power of 1
Authors: Müller et al. Genetic neurodevelopmental disorders are often presented with various degrees of severity and complex syndromes,...
139 views0 comments
- Jul 1, 2021
- 1 min
N-of-1 trial of salbutamol in hyperkalaemic periodic paralysis
Authors: Stunnenberg BC, Merkus EC, Raaphorst J, et al Hyperkalemic periodic paralysis (HyperPP) is a rare neurological channelopathy...
57 views0 comments
- May 31, 2021
- 2 min
Statin Treatment and Muscle Symptoms: Series of Randomised, Placebo Controlled N-of-1 Trials
Authors: Herrett E, Williamson E, Brack K, Beaumont D, Perkins A, Thayne A et al. A recent BMJ article demonstrated the value of N-of-1...
75 views0 comments
- Mar 30, 2021
- 1 min
Comparing the Bayesian Unknown Change-Point Model and Simulation Modeling Analysis to Analyze SCEDs
Natesan, Nandakumar, Palka & Shrestha (2021) Visual analysis has been a common tool used to analyse single-case experimental design...
66 views0 comments
- Nov 30, 2020
- 1 min
Bayesian Adaptive N-of-1 trials for Estimating Population and Individual Treatment Effects
Senarathne, Overstall & McGree (2020) A recent article in Statistics in Medicine proposes an adaptive N-of-1 framework where treatment...
156 views0 comments
- Oct 31, 2020
- 1 min
The Consecutive Controlled Case Series: Design, Data-Analytics, Reporting Methods and Generality
This selected article is about Consecutive Controlled Case Series
161 views0 comments
- Jun 30, 2020
- 2 min
The Possibilities of the Use of N-of-1 and Do-It-Yourself Trials in Nutritional Research
Krone et al. (2020) test whether meta-analysis or linear mixed-modelling approaches are best aggregating N-of-1 data
50 views0 comments
- May 31, 2020
- 1 min
Analysing N-of-1 Observational Data: A 10-Step SPSS Tutorial for Beginners
Authors: McDonald, Vieira & Johnston (2020)
441 views0 comments
- Jan 30, 2020
- 1 min
Protocol for a Randomized Controlled Trial Enhanced with Single-Case Experimental Design
Selected article written by Simons, Harrison, O'Brien, Heirich, Loecher, Boothroyd, Vlaeyen, Wicksell, Schofield, Hood, Orendurff, Chan &...
83 views0 comments
- Aug 30, 2019
- 1 min
A Pilot Study of Amino Acids in Unresectable Non-Small-Cell Lung Cancer Patients During Chemotherapy
Selected paper written by Lian Liu, Yue Zhang, Jia Wei, Zhaoxin Chen, and Jing Yu (2019)
60 views0 comments
- May 31, 2019
- 1 min
Designing Robust N-of-1 Studies for Precision Medicine
Read this month's ICN selected paper!
111 views0 comments
- Mar 31, 2019
- 1 min
Meta-Analysis of Single-Case Research via Multilevel Models
Authors: Dr Mariola Moeyaert, Dr Rumen Manolov, and Dr Emily Rodabaugh Multilevel modeling is an approach that can be used to summarize...
50 views0 comments
- Feb 28, 2019
- 1 min
A SCED Study on Improving Social Communication Skills after Traumatic Brain Injury
Authors: Dr Rachael Rietdijk, Emma Power, Melissa Brunner, Dr Leanne Togher Summary This paper describes a SCED to evaluate telehealth to...
41 views0 comments
- Jan 31, 2019
- 1 min
Evaluation of person-level heterogeneity of treatment effects in multiperson N-of-1 studies
Full title: Evaluation of person-level heterogeneity of treatment effects in published multiperson N-of-1 studies: systematic review and...
73 views0 comments
- Dec 31, 2018
- 1 min
Statistical pitfalls of personalized medicine
Author: Stephen Senn This article describes some key assumptions that have been made in personalised medicine. For example: There is a...
52 views0 comments
- Oct 31, 2018
- 1 min
Methodological standards in single-case experimental design: Raising the bar
Authors: Dr Jennifer B Ganz and Dr Kevin M Ayres This paper summarises the recent history of methodological quality considerations in...
47 views0 comments
- Aug 31, 2018
- 1 min
Randomized single-case AB phase designs: Prospects and pitfalls
Authors: Dr Bart Michiels and Dr Patrick Onghena This paper discusses the randomized AB single-case phase design. Randomized AB...
19 views0 comments