Selected papers

BLOGS AND SELECTED PAPERS

New blogs and selected papers are added on a monthly basis. To receive updates about new posts by email, please join the ICN.

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Aug 21
2 min

Systematic Review of N-of-1 Studies in Rare Genetic Neurodevelopmental Disorders: The Power of 1

Authors: Müller et al. Genetic neurodevelopmental disorders are often presented with various degrees of severity and complex syndromes,...

58 views0 comments

Jun 30
1 min

N-of-1 trial of salbutamol in hyperkalaemic periodic paralysis

Authors: Stunnenberg BC, Merkus EC, Raaphorst J, et al Hyperkalemic periodic paralysis (HyperPP) is a rare neurological channelopathy...

32 views0 comments

May 30
2 min

Statin Treatment and Muscle Symptoms: Series of Randomised, Placebo Controlled N-of-1 Trials

Authors: Herrett E, Williamson E, Brack K, Beaumont D, Perkins A, Thayne A et al. A recent BMJ article demonstrated the value of N-of-1...

55 views0 comments

Mar 30
1 min

Comparing the Bayesian Unknown Change-Point Model and Simulation Modeling Analysis to Analyze SCEDs

Natesan, Nandakumar, Palka & Shrestha (2021) Visual analysis has been a common tool used to analyse single-case experimental design...

50 views0 comments

Nov 30, 2020
1 min

Bayesian Adaptive N-of-1 trials for Estimating Population and Individual Treatment Effects

Senarathne, Overstall & McGree (2020) A recent article in Statistics in Medicine proposes an adaptive N-of-1 framework where treatment...

139 views0 comments

Oct 31, 2020
1 min

The Consecutive Controlled Case Series: Design, Data-Analytics, Reporting Methods and Generality

This selected article is about Consecutive Controlled Case Series

108 views0 comments

Jun 30, 2020
2 min

The Possibilities of the Use of N-of-1 and Do-It-Yourself Trials in Nutritional Research

Krone et al. (2020) test whether meta-analysis or linear mixed-modelling approaches are best aggregating N-of-1 data

37 views0 comments

May 30, 2020
1 min

Analysing N-of-1 Observational Data: A 10-Step SPSS Tutorial for Beginners

Authors: McDonald, Vieira & Johnston (2020)

358 views0 comments

Jan 30, 2020
1 min

Protocol for a Randomized Controlled Trial Enhanced with Single-Case Experimental Design

Selected article written by Simons, Harrison, O'Brien, Heirich, Loecher, Boothroyd, Vlaeyen, Wicksell, Schofield, Hood, Orendurff, Chan &...

79 views0 comments

Sep 30, 2019
1 min

Patient, study thyself

Selected article written by Wicks (2019)

87 views0 comments

Aug 30, 2019
1 min

A Pilot Study of Amino Acids in Unresectable Non-Small-Cell Lung Cancer Patients During Chemotherapy

Selected paper written by Lian Liu, Yue Zhang, Jia Wei, Zhaoxin Chen, and Jing Yu (2019)

60 views0 comments

May 31, 2019
1 min

Designing Robust N-of-1 Studies for Precision Medicine

Read this month's ICN selected paper!

106 views0 comments

Apr 30, 2019
1 min

Personalised Nutrition and Health

Authors: Dr Jose M Ordovas, Dr Lynnette R Ferguson, Dr E Shyong Tai, Dr John C Mathers Summary: In this informative review, Ordovas and...

48 views0 comments

Mar 31, 2019
1 min

Meta-Analysis of Single-Case Research via Multilevel Models

Authors: Dr Mariola Moeyaert, Dr Rumen Manolov, and Dr Emily Rodabaugh Multilevel modeling is an approach that can be used to summarize...

42 views0 comments

Feb 28, 2019
1 min

A SCED Study on Improving Social Communication Skills after Traumatic Brain Injury

Authors: Dr Rachael Rietdijk, Emma Power, Melissa Brunner, Dr Leanne Togher Summary This paper describes a SCED to evaluate telehealth to...

30 views0 comments

Jan 31, 2019
1 min

Evaluation of person-level heterogeneity of treatment effects in multiperson N-of-1 studies

Full title: Evaluation of person-level heterogeneity of treatment effects in published multiperson N-of-1 studies: systematic review and...

72 views0 comments

Dec 31, 2018
1 min

Statistical pitfalls of personalized medicine

Author: Stephen Senn This article describes some key assumptions that have been made in personalised medicine. For example: There is a...

46 views0 comments

Oct 31, 2018
1 min

Methodological standards in single-case experimental design: Raising the bar

Authors: Dr Jennifer B Ganz and Dr Kevin M Ayres This paper summarises the recent history of methodological quality considerations in...

26 views0 comments

Aug 31, 2018
1 min

Randomized single-case AB phase designs: Prospects and pitfalls

Authors: Dr Bart Michiels and Dr Patrick Onghena This paper discusses the randomized AB single-case phase design. Randomized AB...

16 views0 comments

Jul 31, 2018
1 min

Melatonin in Youth: N-of-1 trials in a stimulant-treated ADHD Population (MYNAP): study protocol

Authors: Dr Salima Punja, Dr Catherine J. Nikles , Dr Hugh Senior, Dr Geoffrey Mitchell, Dr Christopher H. Schmid, Dr Helen Heussler, Dr...

25 views0 comments

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N-of-1 Clinical Trials and Single-Case Designs