• ICN

Evaluation of person-level heterogeneity of treatment effects in multiperson N-of-1 studies


Full title: Evaluation of person-level heterogeneity of treatment effects in published multiperson N-of-1 studies: systematic review and reanalysis


Authors: Dr Gowri Raman, Dr Ethan M Balk, Dr Lana Lai, Dr Jennifer Shi, Dr Jeffrey Chan, Dr Jennifer S Lutz, Dr Robert W Dubois, Dr Richard L Kravitz, Dr David M Kent


Summary

This systematic review and reanalysis of 62 multi-person N-of-1 studies found identified statistically significant person-level heterogeneity of treatment effects in 8 of the 13 studies (62%) reporting person-level treatment effects and in 8 of the 14 studies (57%) reporting person-level outcomes. The authors concluded that person-level heterogeneity

of treatment effects is common and often substantial and called for improved assessment and reporting of person-level treatment effects in multi-person N-of-1 studies.


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