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Advancing Individualised Science

The International Collaborative Network for N-of-1 Trials and Single-Case Designs (ICN) is a global network of researchers, academics, clinicians, and consumers from around the world who are interested in N-of-1 trials and single-case designs to understand and improve outcomes for individuals and groups.

Get involved! Join the ICN to stay up-to-date about what is happening in the field including methodological developments, collaborative opportunities, training initiatives and more.

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Last updated July 2024

N-of-1 and single-case design vision and mission

The ICN's vision is a world where personalised clinical studies (for both single and groups of individuals) are an integral part of clinical practice and health research. Read more about the ICN mission and objectives here. To find out more about the strategic priorities of the ICN please click here to read the ICN position paper.

N-of-1 and single-case design collaborative network

The ICN aims to encourage discussion and collaboration amongst members through the content and features on this website. Members are encouraged to write Blogs and use the Discussion Forum to share new ideas, update others about current projects and events, discuss key research papers and ask questions.

Accelerating therapy development, application, and evaluation for individuals with rare genetic diseases

Accelerating therapy development, application, and evaluation for individuals with rare genetic diseases

Accelerating therapy development, application, and evaluation for individuals with rare genetic diseases

Apr 25 min read

N-of-1 trials and single-case experimental designs in physiotherapy for musculoskeletal conditions

N-of-1 trials and single-case experimental designs in physiotherapy for musculoskeletal conditions

N-of-1 trials and single-case experimental designs in physiotherapy for musculoskeletal conditions

Mar 1, 20234 min read

Single-Case Studies as a Hot Topic in Pain Research: A Conference Review

Single-Case Studies as a Hot Topic in Pain Research: A Conference Review

Single-Case Studies as a Hot Topic in Pain Research: A Conference Review

Jun 30, 20223 min read

Brave New World of Health Care Consumerism, N-of-1, and Character of Health Type

Brave New World of Health Care Consumerism, N-of-1, and Character of Health Type

Brave New World of Health Care Consumerism, N-of-1, and Character of Health Type

Aug 22, 20216 min read

Implementing Single-Case Designs in Complementary and Alternative Medicine Trials

Implementing Single-Case Designs in Complementary and Alternative Medicine Trials

Implementing Single-Case Designs in Complementary and Alternative Medicine Trials

Jul 1, 20215 min read

Who Will Benefit from Which Diet: Can N-of-1 Studies Fill a Gap in the Care of Adult PKU?

Who Will Benefit from Which Diet: Can N-of-1 Studies Fill a Gap in the Care of Adult PKU?

Who Will Benefit from Which Diet: Can N-of-1 Studies Fill a Gap in the Care of Adult PKU?

May 31, 20214 min read

Will the Real Mr. Average Please Stand Up?

Will the Real Mr. Average Please Stand Up?

Will the Real Mr. Average Please Stand Up?

Mar 30, 20215 min read

N-of-1 Trials are Valuable Scientific Methods for Personalised Medicine

N-of-1 Trials are Valuable Scientific Methods for Personalised Medicine

N-of-1 Trials are Valuable Scientific Methods for Personalised Medicine

Nov 30, 20204 min read

Creating Evidence from Real World Patient Digital Data

Creating Evidence from Real World Patient Digital Data

Creating Evidence from Real World Patient Digital Data

Oct 31, 20204 min read

N-of-1 Trials in Practice: A Training Program for Complementary Medicine Practitioners

N-of-1 Trials in Practice: A Training Program for Complementary Medicine Practitioners

N-of-1 Trials in Practice: A Training Program for Complementary Medicine Practitioners

Jun 30, 20205 min read

Progress Towards Priorities for the International Collaborative Network for N-of-1 Trials and SCDs

Progress Towards Priorities for the International Collaborative Network for N-of-1 Trials and SCDs

Progress Towards Priorities for the International Collaborative Network for N-of-1 Trials and SCDs

May 31, 20203 min read

Visualization of Individual Data: A Powerful Tool in Personalized Medicine

Visualization of Individual Data: A Powerful Tool in Personalized Medicine

Visualization of Individual Data: A Powerful Tool in Personalized Medicine

Jan 30, 20203 min read

Going Paperless: How Digital Technology Can Shape the Field of N-of-1 Trials

Going Paperless: How Digital Technology Can Shape the Field of N-of-1 Trials

Going Paperless: How Digital Technology Can Shape the Field of N-of-1 Trials

Sep 30, 20193 min read

N-of-1 Trials in CAM: The New Frontier for Generating Practice-Based Evidence?

N-of-1 Trials in CAM: The New Frontier for Generating Practice-Based Evidence?

N-of-1 Trials in CAM: The New Frontier for Generating Practice-Based Evidence?

Aug 30, 20193 min read

The Rare Disease Registry and Analytics Platform: Paving the way forward for N-of-1 trials

The Rare Disease Registry and Analytics Platform: Paving the way forward for N-of-1 trials

The Rare Disease Registry and Analytics Platform: Paving the way forward for N-of-1 trials

May 31, 20192 min read

Is There a Role for N-of-1 Trials in Nutrition Research?

Is There a Role for N-of-1 Trials in Nutrition Research?

Is There a Role for N-of-1 Trials in Nutrition Research?

Apr 30, 20194 min read

Evaluation of a Physical Activity Intervention for Individuals with Whiplash Associated Disorders

Evaluation of a Physical Activity Intervention for Individuals with Whiplash Associated Disorders

Evaluation of a Physical Activity Intervention for Individuals with Whiplash Associated Disorders

Mar 31, 20193 min read

Using N-of-1 Trials to Identify Responders to Melatonin for Sleep Disturbance in Parkinson's Disease

Using N-of-1 Trials to Identify Responders to Melatonin for Sleep Disturbance in Parkinson's Disease

Using N-of-1 Trials to Identify Responders to Melatonin for Sleep Disturbance in Parkinson's Disease

Feb 28, 20194 min read

Effect of mexiletine on muscle stiffness in nondystrophic myotonia: aggregated N-of-1 trials

Effect of mexiletine on muscle stiffness in nondystrophic myotonia: aggregated N-of-1 trials

Effect of mexiletine on muscle stiffness in nondystrophic myotonia: aggregated N-of-1 trials

Jan 31, 20193 min read

10 key take-home messages from an expert workshop on single-case methodology

10 key take-home messages from an expert workshop on single-case methodology

10 key take-home messages from an expert workshop on single-case methodology

Dec 31, 20183 min read

ICN Blogs & Interviews with Thought Leaders

An Interview with A/Professor Rumen Manolov, Thought Leader in the Field of Single-Case Designs

An Interview with A/Professor Rumen Manolov, Thought Leader in the Field of Single-Case Designs

An Interview with A/Professor Rumen Manolov, Thought Leader in the Field of Single-Case Designs

Rumen Manolov is an associate professor at the Faculty of Psychology, University of Barcelona. He is a psychologist with PhD training in...

An Interview with Professor Patrick Onghena, Thought Leader in the Field of Single-Case Designs

An Interview with Professor Patrick Onghena, Thought Leader in the Field of Single-Case Designs

An Interview with Professor Patrick Onghena, Thought Leader in the Field of Single-Case Designs

Patrick Onghena is full professor of statistics and methodology at the Faculty of Psychology and Educational Sciences, KU Leuven...

An Interview with Professor Johan Vlaeyen, Thought Leader in the Field of Single-Case Designs

An Interview with Professor Johan Vlaeyen, Thought Leader in the Field of Single-Case Designs

An Interview with Professor Johan Vlaeyen, Thought Leader in the Field of Single-Case Designs

Johan W. S. Vlaeyen is professor at the Universities of Leuven, Belgium and Maastricht, Netherlands. His main research expertise is on...

An Interview with Professor Nicholas Schork, Thought Leader in the Field of Single-Case Designs

An Interview with Professor Nicholas Schork, Thought Leader in the Field of Single-Case Designs

An Interview with Professor Nicholas Schork, Thought Leader in the Field of Single-Case Designs

Dr. Nicholas Schork is Deputy Director and Distinguished Professor of Quantitative Medicine at The Translational Genomics Research...

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